Total:€ 1.282,00
Vitamins and Methylation Cofactors Markers
€ 119,00
Comprehensive insight into micronutrient status and cellular metabolism
Your test at a glance
- Sample
- Urine
- Results from receipt
- Usually 3–10 days
- Fasting
- An overnight fast is usually not needed. Follow the kit’s food, drink and collection-timing instructions.
Timing starts when suitable samples arrive at the laboratory. Shipping time is additional. Combined panels may take longer.
Preparation: Pause non-prescribed nutritional supplements for at least 48 hours, unless WHL or your clinician advises otherwise.
WHL will send the full test instructions with your kit or appointment confirmation. Follow these before collecting.
Preparation and important notesOne charge per request. Processing and handling is charged once for the complete request, not for each test or panel. Collection and delivery charges are shown separately at checkout.
Description
Unlock Functional Clarity with Biochemical Precision
This advanced urine-based panel offers a functional and clinically validated assessment of vitamin sufficiency and methylation cofactor needs by analyzing a broad array of organic acid biomarkers. Rather than relying solely on serum levels, which may not reflect intracellular activity, this test evaluates metabolic intermediates that reflect how vitamins are being used at the cellular level—offering a true picture of physiological need.
What This Panel Measures
The panel assesses a wide spectrum of vitamin-related and methylation-related metabolites, including:
- Functional B-vitamin markers (B1, B2, B3, B5, B6, B7, B9, B12)
- Organic acids indicating vitamin need such as methylmalonic acid, glutaric acid, and xanthurenic acid
- Indicators of mitochondrial function and energy metabolism like succinic, malic, and α-ketoglutaric acid
- Markers related to methylation including FIGLU, uracil, thymine, and kynurenic acid
Clinical Applications
This panel is ideal for individuals or patients with:
- Fatigue, depression, poor stress tolerance
- Suspected vitamin deficiencies or poor nutrient absorption
- Autism spectrum disorders and neurological symptoms
- High oxidative stress or inflammation
- Mitochondrial dysfunction or metabolic disorders
- Use of oral contraceptives or other medications affecting B-vitamin status
By identifying specific biochemical imbalances, clinicians can personalize supplementation strategies with precision and confidence.
Key Biomarkers and Their Significance
| Marker | Clinical Insight |
|---|---|
| Methylmalonic Acid | Elevated levels suggest vitamin B12 deficiency |
| Pyridoxic Acid | Low levels reflect B6 insufficiency; high levels indicate recent B6 intake |
| Formiminoglutamic Acid (FIGLU) | Marker of folic acid deficiency or impaired methylation |
| Xanthurenic & Kynurenic Acids | Related to tryptophan metabolism; elevated in B6 deficiency and chronic inflammation |
| Glutaric & Succinic Acid | Linked to riboflavin (B2) status and mitochondrial function |
| Uracil & Thymine | Indicators of folate-driven methylation efficiency |
| α-Ketoglutaric & Malic Acids | Reflect needs for B1, B2, B3, B5, and mitochondrial cofactors like CoQ10 |
This table highlights key functional indicators, but the full panel also measures a broader range of clinically significant metabolites, including Uracil, Thymine, Ethylmalonic Acid, 3-Hydroxy-3-methylglutaric Acid, N-Acetylcysteine Acid, Methylcitric Acid, Pantothenic Acid, Picolinic Acid, Pimelic Acids, 3-Methylglutaric Acid, 3-Methylglutaconic Acid, β-Hydroxyisovaleric Acid, α-Ketoisovaleric Acid, α-Ketoisocapric Acid, α-Keto-β-methylvaleric Acid, Succinic Acid, Malic Acid, α-Ketoglutaric Acid, and Ascorbic Acid.
These additional markers provide further insight into mitochondrial performance, detoxification needs, oxidative stress, and nutrient utilization, making this panel one of the most comprehensive tools available for functional assessment.
Why Use This Panel?
Conventional nutrient tests often miss subtle intracellular imbalances. This panel bridges that gap by:
- Detecting functional nutrient needs before clinical deficiency develops
- Supporting methylation pathway assessments, vital for neurological, cardiovascular, and detoxification health
- Aiding in the interpretation of symptoms that are otherwise non-specific or multifactorial
Sample Type & Preparation
- Specimen: First morning urine (non-preserved)
- Shipping: Cold pack recommended. Full instructions provided upon ordering.
- Turnaround Time: Typically 2-7 business days from sample receipt
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- Includes: Assessment of various vitamins and methylation cofactors
- Sample requirement: First-morning urine sample
Suitable for postal submission.
Additional information
| Weight | 0,5 kg |
|---|---|
| Dimensions | 16 cm |
| Sample Type |
Preparing for this test
WHL will send detailed collection, storage and return instructions with your test kit or appointment confirmation. Those test-specific instructions take priority.
Sample: Urine
Fasting: An overnight fast is usually not needed. Follow the kit’s food, drink and collection-timing instructions.
For nutritional testing, pause non-prescribed supplements, including protein and amino-acid powders, for at least 48 hours unless WHL or your clinician advises otherwise. If monitoring supplements, agree the timing with your practitioner.
The collection time, container and storage depend on the test. Follow your WHL kit; do not switch between a spot sample and a 24-hour collection.
Do not stop prescribed medicines or prescribed supplements without advice from your treating clinician. Tell WHL about high-dose biotin; some tests need a longer pause. A short supplement pause does not remove all effects of long-term use.
If another test in the same order requires fasting, follow the combined instructions. Ask your clinician or WHL before fasting if you have diabetes, use glucose-lowering medicine, are pregnant, or are arranging testing for a child.
When to expect your results
Usually 3–10 days. This estimate starts when suitable samples reach the laboratory, not on the order or collection date. Shipping is additional. WHL will confirm any test-specific exception; a combined panel follows its slowest component.
Practical preparation tips
If fasting is requested, drink only plain water in your usual amounts. Do not have coffee, tea, juice, milk, energy drinks, sweets or chewing gum. Avoid smoking or vaping that morning. Book an early appointment and eat after collection.
For a planned blood test, avoid alcohol and unusually strenuous exercise for 24 hours, where practical, and sit quietly for about 15 minutes before collection. Tell WHL if you could not follow the preparation instructions.
Do not extend fasting or change prescribed medication on your own. Ask your clinician first if you have diabetes, need medicine with food, are pregnant, or are arranging testing for a child. WHL’s full test-specific instructions take priority.
Sources for this general preparation guidance
- Mayo Clinic Laboratories — plasma amino acids
- Mayo Clinic Laboratories — vitamin B6
- Mayo Clinic Laboratories — B12 and folate
- Mayo Clinic Laboratories — vitamins A and E
- Mayo Clinic Laboratories — iron studies
- NHS — fasting blood tests
- EAS/EFLM — fasting and non-fasting lipids
- EFLM/COLABIOCLI — preparation for blood collection
Other laboratories’ methods and preparation rules can differ. These sources support the general advice; WHL confirms the instructions for the method used for your test.