test tube

LTT – Substance Intolerance (Custom Test)

€ 71,00

Custom LTT testing to a specific substance provided by the clinician or patient.
Sample collection must take place at World Health Laboratories (WHL) or be delivered with ice to the lab on the same day of collection before 2:00 PM.

Your test at a glance

Sample
Blood
Results from receipt
WHL will confirm the reporting time for this test
Fasting
Check your WHL instructions before collection

Timing starts when suitable samples arrive at the laboratory. Shipping time is additional. Combined panels may take longer.

WHL will send the full test instructions with your kit or appointment confirmation. Follow these before collecting.

Preparation and important notes

One charge per request. Processing and handling is charged once for the complete request, not for each test or panel. Collection and delivery charges are shown separately at checkout.

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SKU: LTTB-SI Categories: Tag:

Description

Includes

This is a customised Lymphocyte Transformation Test (LTT) designed to evaluate immune reactivity to a specific substance provided by the clinician or patient.

Requirements
  • A minimum of 1 gram of the test substance must be supplied for analysis
Examples of substances that can be tested
  • Specific food-related chemicals or additives
  • Environmental toxins or industrial chemicals
  • Occupational exposure substances
  • Selected pharmaceutical compounds
Lymphocyte Transformation Test (LTT)

The Lymphocyte Transformation Test (LTT) evaluates cell-mediated (Type IV) hypersensitivity reactions by measuring lymphocyte proliferation after exposure to specific substances in vitro.

Unlike IgE allergy tests, LTT detects delayed immune reactions, which are often involved in:

  • chronic inflammation
  • unexplained fatigue
  • neurological symptoms
  • implant intolerance
  • dental material intolerance
  • multi-chemical sensitivity

This makes LTT particularly useful in environmental medicine, dentistry, and implant compatibility assessment.

Clinical value

This test allows for a highly individualised assessment of immune sensitivity, particularly in patients with unexplained symptoms where exposure to a specific compound is suspected. It supports targeted avoidance strategies and personalised clinical decision-making.

Interpretation Notes

LTT results indicate:

  • degree of lymphocyte activation
  • potential delayed hypersensitivity
  • immune system recognition of substances

Results should be interpreted alongside:

  • clinical history
  • symptom patterns
  • exposure history
  • other immune markers
Why WHL LTT testing is valuable
  • Supports complex chronic cases
  • Adds objective immune data
  • Guides implant and dental material selection
  • Helps explain unexplained inflammatory symptoms
  • Complements toxicology and mineral panels

Read more……..

  • Sample requirement: Whole blood

Additional information

Weight 0,5 kg
Dimensions 25 × 16 × 2,5 cm
Sample Type

Preparing for this test

WHL will send detailed collection, storage and return instructions with your test kit or appointment confirmation. Those test-specific instructions take priority.

Sample: Blood

Fasting: Check your WHL instructions before collection

Do not stop prescribed medicines or prescribed supplements without advice from your treating clinician. Tell WHL about high-dose biotin; some tests need a longer pause. A short supplement pause does not remove all effects of long-term use.

If another test in the same order requires fasting, follow the combined instructions. Ask your clinician or WHL before fasting if you have diabetes, use glucose-lowering medicine, are pregnant, or are arranging testing for a child.

When to expect your results

WHL will confirm the reporting time for this test. This estimate starts when suitable samples reach the laboratory, not on the order or collection date. Shipping is additional. WHL will confirm any test-specific exception; a combined panel follows its slowest component.

Read WHL’s general preparation and reporting guidance

Practical preparation tips

If fasting is requested, drink only plain water in your usual amounts. Do not have coffee, tea, juice, milk, energy drinks, sweets or chewing gum. Avoid smoking or vaping that morning. Book an early appointment and eat after collection.

For a planned blood test, avoid alcohol and unusually strenuous exercise for 24 hours, where practical, and sit quietly for about 15 minutes before collection. Tell WHL if you could not follow the preparation instructions.

Do not extend fasting or change prescribed medication on your own. Ask your clinician first if you have diabetes, need medicine with food, are pregnant, or are arranging testing for a child. WHL’s full test-specific instructions take priority.

Sources for this general preparation guidance

Other laboratories’ methods and preparation rules can differ. These sources support the general advice; WHL confirms the instructions for the method used for your test.

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