Adrenal Corticoids Profile (Urine)

Beschrijving

What this test evaluates

This profile includes a wide spectrum of adrenal corticoids and metabolites, giving a deep understanding of adrenal output and metabolic enzyme activity.

Primary Adrenal Hormones

• Cortisol
• Cortisone
• Tetrahydrocortisol (THF)
• Tetrahydrocortisone (THE)
• Allo-THF
• Corticosterone
• Allo-Tetrahyrdocorticosterone (allo-THB)
• Tetrahydrocorticosterone (THB)

Mineralocorticoid Pathway

• Aldosterone metabolites (THA, THB-series)

Androgen Pathway Markers

(Useful for cross-checking adrenal androgen contribution)

• DHEA metabolites (optional depending on laboratory setup)
• Androsterone
• Etiocholanolone

Ratios and Interpretation Insights

• Cortisol/cortisone balance (11β-HSD activity)
• 5α-reductase and 5β-reductase activity
• Total adrenal output
• Metabolic clearance patterns
• Indicators of HPA-axis dysfunction

This broader view helps clinicians distinguish between low production, excessive turnover, or impaired metabolic conversion, which is essential for accurate treatment planning.

Who should consider this test?

The Adrenal Corticoids Profile may be useful in individuals experiencing:

• Persistent fatigue or burnout
• Chronic stress exposure
• Sleep difficulties
• Daytime energy crashes
• Poor stress tolerance
• Mood swings or irritability
• Suspected cortisol imbalance
• Post-viral fatigue syndromes
• Hormonal symptoms not explained by sex-hormone testing alone

This panel is also helpful for monitoring recovery programs, adrenal-support therapies, and stress-modulating interventions.

Why urine testing?

Urine analysis offers a detailed look at both free hormones and downstream metabolites, which allows for:

• A more complete view of adrenal steroidogenesis
• Assessment of enzyme pathways and metabolic activity
• Detection of hidden dysregulation not visible in serum
• Better understanding of chronic patterns instead of single time-point measurements

For complex cases, urine metabolite testing is considered more informative than isolated blood cortisol values.

Sample requirements

• Sample type: Urine
• Collection: Spot–timed collection
• Shipping: Return shipping logistics included in your WHL kit
• Stability: Samples remain stable with provided preservatives

Full instructions are included in the test kit.

What you will receive

• A detailed laboratory report with numerical values and reference ranges
• Interpretation comments based on metabolic patterns
• Clinical insights into adrenal output, conversion pathways and enzymatic function
• Practical direction for further assessment where relevant

Suitable for postal submission.