Total:€ 624,00
Metabolic & Cofactor Insight – Organic Acids + Vitamin Panel 16
€ 559,00
An integrated blood and urine assessment combining more than 95 urinary organic-acid metabolites with direct measurement of vitamins, active coenzyme forms, antioxidants, carotenoids, CoQ10 and carnitine. The panel helps connect functional metabolic patterns with cofactor availability across mitochondrial energy production, methylation, neurotransmitter metabolism and antioxidant defence.
Beschrijving
Integrated metabolic assessment
Connect metabolic pathway patterns with the cofactors that support them
The Metabolic & Cofactor Insight panel combines the Organic Acids Test with Vitamin Panel 16. Together, they evaluate functional metabolic output alongside directly measured vitamins, active coenzyme forms, antioxidants, carotenoids, CoQ10 and carnitine.
Why combine these two tests?
Organic acids are downstream products of cellular metabolism. Their patterns may suggest altered pathway flux, increased metabolic demand, microbial contribution, oxidative stress or reduced efficiency of nutrient-dependent enzymatic reactions. However, an organic-acid pattern alone does not establish that a specific vitamin is deficient.
Vitamin Panel 16 adds a complementary biochemical perspective by measuring circulating vitamins and related nutrient systems involved in these reactions. Combining functional metabolites with direct nutrient measurements helps the practitioner determine whether findings are concordant or whether other influences—such as altered utilisation, enzyme inhibition, increased turnover, medication effects, dietary substrate load or impaired absorption—should be considered.
The clinical advantage of the combined panel
Concordant findings—for example, a low directly measured nutrient together with a compatible functional metabolite pattern—may strengthen the case for clinically relevant insufficiency.
Discordant findings—such as an abnormal functional marker despite apparently adequate circulating nutrient status—may direct attention toward utilisation, transport, enzyme activity, oxidative demand, renal handling or other upstream influences rather than simple replacement alone.
Included test 1
Organic Acids Test
Measures more than 95 urinary metabolites related to mitochondrial energy pathways, nutrient-dependent reactions, methylation, neurotransmitter metabolism, oxalate handling, detoxification and selected microbial metabolites.
Included test 2
Vitamin Panel 16
Assesses fat- and water-soluble vitamins together with selected active coenzyme forms, carotenoids, antioxidant nutrients, CoQ10 and the carnitine profile, providing direct context for multiple metabolic pathways.
Clinical and biochemical perspective
Mitochondrial energy production
Krebs-cycle, glycolytic and fatty-acid oxidation metabolites can be interpreted alongside thiamine, riboflavin, niacin-related status, pantothenic acid, biotin, CoQ10 and carnitine. These nutrients support dehydrogenase activity, electron transfer, coenzyme A formation and mitochondrial substrate transport.
Krebs-cycle, glycolytic and fatty-acid oxidation metabolites can be interpreted alongside thiamine, riboflavin, niacin-related status, pantothenic acid, biotin, CoQ10 and carnitine. These nutrients support dehydrogenase activity, electron transfer, coenzyme A formation and mitochondrial substrate transport.
Methylation and one-carbon metabolism
Functional markers such as methylmalonic acid, FIGLU and related metabolites may be considered together with measured folate, vitamin B12, riboflavin and vitamin B6 status. This supports a more differentiated assessment of nutrient availability versus altered cofactor utilisation or increased pathway demand.
Functional markers such as methylmalonic acid, FIGLU and related metabolites may be considered together with measured folate, vitamin B12, riboflavin and vitamin B6 status. This supports a more differentiated assessment of nutrient availability versus altered cofactor utilisation or increased pathway demand.
Neurotransmitter-related metabolism
Urinary metabolites related to tryptophan and catecholamine pathways can be reviewed with vitamin B6, riboflavin, folate, vitamin B12, vitamin C and other nutrient systems involved in synthesis, conversion and degradation. These findings remain peripheral metabolic indicators and should not be interpreted as direct measurements of brain neurotransmitter concentrations.
Urinary metabolites related to tryptophan and catecholamine pathways can be reviewed with vitamin B6, riboflavin, folate, vitamin B12, vitamin C and other nutrient systems involved in synthesis, conversion and degradation. These findings remain peripheral metabolic indicators and should not be interpreted as direct measurements of brain neurotransmitter concentrations.
Oxidative balance and cellular protection
Organic-acid markers associated with oxidative or glutathione demand can be considered alongside vitamins C and E, carotenoids and CoQ10. This helps distinguish limited antioxidant availability from increased oxidative consumption, although it does not directly quantify oxidative tissue damage.
Organic-acid markers associated with oxidative or glutathione demand can be considered alongside vitamins C and E, carotenoids and CoQ10. This helps distinguish limited antioxidant availability from increased oxidative consumption, although it does not directly quantify oxidative tissue damage.
Absorption, diet and metabolic demand
Direct nutrient measurements provide information about current biochemical status, while organic-acid patterns may reflect how nutrients are being used within metabolic pathways. Divergence between the two may warrant consideration of gastrointestinal absorption, dietary intake, supplementation, medication, renal function and inflammatory or metabolic demand.
Direct nutrient measurements provide information about current biochemical status, while organic-acid patterns may reflect how nutrients are being used within metabolic pathways. Divergence between the two may warrant consideration of gastrointestinal absorption, dietary intake, supplementation, medication, renal function and inflammatory or metabolic demand.
What the combined assessment covers
Cellular energyGlycolysis, Krebs-cycle intermediates, fatty-acid utilisation, CoQ10 and carnitine context.
Vitamin-dependent pathwaysFunctional metabolite patterns assessed alongside directly measured vitamin and coenzyme status.
Redox regulationAntioxidant availability considered in relation to markers associated with oxidative and glutathione demand.
Neurochemical pathwaysTryptophan and catecholamine-related metabolites interpreted with relevant nutrient cofactors.
Methylation supportFolate- and B12-related functional markers reviewed with directly measured nutrient status.
Microbial metabolitesSelected yeast- and bacteria-associated metabolites considered within the broader nutritional and metabolic context.
Who may consider this panel?
- People investigating persistent fatigue, reduced stamina or impaired recovery
- Individuals with restrictive diets, suspected malabsorption or complex supplementation needs
- People with metabolic, neurological or gastrointestinal symptoms requiring broader biochemical context
- Clients with persistent symptoms despite unremarkable routine laboratory results
- Practitioners seeking to distinguish nutrient availability from altered metabolic utilisation
Sample requirements
Organic Acids: approximately 10 mL first-morning midstream urine collected using the supplied materials.
Vitamin Panel 16: venous blood collected by a qualified blood-draw professional using the supplied collection kit.
Sample types: blood and urine.
Submission: suitable for postal submission when the supplied collection, storage and transport instructions are followed.
Preparation and collection
- Collect the Organic Acids sample from the first-morning midstream urine.
- Avoid apples, grapes, pears, raisins, cranberries and wine for 48 hours before urine collection.
- Unless your treating professional advises otherwise, avoid nutritional supplements for three days before sample collection so that both component tests are prepared consistently.
- Do not stop prescribed medication or medically necessary supplementation without the approval of your treating professional.
- Record recent antibiotics, medication and supplement use because these factors may influence interpretation.
- Follow the supplied instructions for blood collection, sample identification, urine storage and return transport.
Turnaround time and reporting
Because the component analyses have different processing schedules, allow approximately 10–14 working days after all suitable samples have arrived at the laboratory.
You receive laboratory reports with measured results and reference ranges for both tests, with interpretive comments where applicable. Integrated professional interpretation is recommended when results are complex or discordant.
How to interpret the results
The combined panel is most informative when the results are evaluated as patterns rather than isolated abnormalities. A functional metabolite may be influenced by several enzymes and cofactors, while a circulating vitamin concentration does not always reflect intracellular utilisation. Interpretation should therefore consider symptom pattern, diet, supplement exposure, medication, renal and hepatic function, gastrointestinal status and relevant routine laboratory findings.
This panel can support targeted nutritional and metabolic assessment, but it is not a stand-alone diagnostic test and should not be used to infer a disease or prescribe treatment from a single marker.
Related and complementary tests
Elements in Blood IIIConsider when mineral balance, trace elements or potentially toxic elements are a primary clinical question.
Plasma Amino AcidsAdds direct information about amino-acid availability, protein metabolism and metabolic substrates.
Oxidative Stress ProfileMeasures oxidative DNA and lipid damage when direct assessment of oxidative burden is required.
GI360 Advanced Stool AnalysisA broader gastrointestinal investigation when dysbiosis, infection, digestion or inflammation is the main concern.
Plasma Amino AcidsAdds direct information about amino-acid availability, protein metabolism and metabolic substrates.
Oxidative Stress ProfileMeasures oxidative DNA and lipid damage when direct assessment of oxidative burden is required.
GI360 Advanced Stool AnalysisA broader gastrointestinal investigation when dysbiosis, infection, digestion or inflammation is the main concern.
Important: This panel supports biochemical and nutritional assessment. It does not by itself diagnose a disease, establish the cause of symptoms or replace medical evaluation. Results should be interpreted with clinical history, diet, medication, supplementation and other relevant investigations.