Persistent Organochlorine Panel – Blood

Beschrijving

Why blood is appropriate for this panel

Persistent organochlorine pesticides are:

• Highly lipophilic
• Slowly eliminated
• Stored in adipose tissue
• Detectable in serum over long periods

This makes blood (serum) a valid and clinically meaningful matrix, unlike modern pesticides which require urine testing.

Analytes included

Persistent organochlorine pesticides

• Pentachlorophenol (PCP)
• Lindane (γ-HCH)
• DDT
• DDE (primary DDT metabolite)
• Hexachlorobenzene (HCB)

These compounds are classified as persistent organic pollutants (POPs) and are subject to international restriction, yet remain detectable due to historical and environmental exposure.

Why these compounds matter clinically

Biological effects

Persistent organochlorines are associated with:

• Endocrine disruption (thyroid, estrogen, androgen signaling)
• Neurotoxicity and cognitive effects
• Immune dysregulation
• Metabolic disturbances
• Mitochondrial and oxidative stress

Common exposure sources

• Historical agricultural pesticide use
• Contaminated soil and dust
• Imported foods
• Fatty animal products
• Old treated wood, paints, and building materials

Sample & methodology

• Sample: Serum (venous blood)
• Method: GC-MS / GC-MS/MS
• Turnaround time: Approximately 10–15 working days
• Fasting sample: Recommended

Suitable for postal submission.