LTT – Substance Intolerance (Custom Test)

Beschrijving

Includes

This is a customised Lymphocyte Transformation Test (LTT) designed to evaluate immune reactivity to a specific substance provided by the clinician or patient.

Requirements

• A minimum of 1 gram of the test substance must be supplied for analysis

Examples of substances that can be tested

• Specific food-related chemicals or additives
• Environmental toxins or industrial chemicals
• Occupational exposure substances
• Selected pharmaceutical compounds

Lymphocyte Transformation Test (LTT)

The Lymphocyte Transformation Test (LTT) evaluates cell-mediated (Type IV) hypersensitivity reactions by measuring lymphocyte proliferation after exposure to specific substances in vitro.

Unlike IgE allergy tests, LTT detects delayed immune reactions, which are often involved in:

• chronic inflammation
• unexplained fatigue
• neurological symptoms
• implant intolerance
• dental material intolerance
• multi-chemical sensitivity

This makes LTT particularly useful in environmental medicine, dentistry, and implant compatibility assessment.

Clinical value

This test allows for a highly individualised assessment of immune sensitivity, particularly in patients with unexplained symptoms where exposure to a specific compound is suspected. It supports targeted avoidance strategies and personalised clinical decision-making.

Interpretation Notes

LTT results indicate:

• degree of lymphocyte activation
• potential delayed hypersensitivity
• immune system recognition of substances

Results should be interpreted alongside:

• clinical history
• symptom patterns
• exposure history
• other immune markers

Why WHL LTT testing is valuable

• Supports complex chronic cases
• Adds objective immune data
• Guides implant and dental material selection
• Helps explain unexplained inflammatory symptoms
• Complements toxicology and mineral panels

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• Sample requirement: Whole blood