LTT – Plastics

Beschrijving

Includes

• Methyl methacrylate (MMA)
• 2-Hydroxyethyl methacrylate (HEMA)
• Triethylene glycol dimethacrylate (TEGDMA)
• Dibenzoyl peroxide (DBP)
• Bisphenol A glycidyl methacrylate (BisGMA)
• Urethane dimethacrylate (UDMA)

Lymphocyte Transformation Test (LTT)

The Lymphocyte Transformation Test (LTT) evaluates cell-mediated (Type IV) hypersensitivity reactions by measuring lymphocyte proliferation after exposure to specific substances in vitro.

Unlike IgE allergy tests, LTT detects delayed immune reactions, which are often involved in:

• chronic inflammation
• unexplained fatigue
• neurological symptoms
• implant intolerance
• dental material intolerance
• multi-chemical sensitivity

This makes LTT particularly useful in environmental medicine, dentistry, and implant compatibility assessment.

Clinical purpose

This test evaluates cell-mediated immune reactivity (Type IV hypersensitivity) to commonly used dental and industrial plastic monomers. These substances are widely present in dental composites, resins, and prosthetic materials and may trigger delayed immune responses in susceptible individuals.

Why this matters

Plastic monomers can contribute to:

• Oral and mucosal irritation
• Immune system activation and chronic inflammation
• Potential endocrine-disrupting effects
• Neurological or systemic symptoms in sensitive individuals

Because these reactions are delayed and not IgE-mediated, they are often not detected by standard allergy testing.

Typical exposure sources

• Dental composite fillings and bonding agents
• Dental prosthetics and orthodontic materials
• Occupational exposure in dentistry, laboratories, or plastics manufacturing

Interpretation Notes

LTT results indicate:

• degree of lymphocyte activation
• potential delayed hypersensitivity
• immune system recognition of substances

Results should be interpreted alongside:

• clinical history
• symptom patterns
• exposure history
• other immune markers

Why WHL LTT testing is valuable

• Supports complex chronic cases
• Adds objective immune data
• Guides implant and dental material selection
• Helps explain unexplained inflammatory symptoms
• Complements toxicology and mineral panels

Read more……..

• Sample requirement: Whole blood