{"id":13312,"date":"2025-11-19T15:35:17","date_gmt":"2025-11-19T14:35:17","guid":{"rendered":"https:\/\/www.worldhealthlaboratories.com\/?post_type=product&#038;p=13312"},"modified":"2026-02-01T00:30:06","modified_gmt":"2026-01-31T23:30:06","slug":"melatonine-profiel-speeksel","status":"publish","type":"product","link":"https:\/\/www.worldhealthlaboratories.com\/nl\/tests\/panels\/melatonin-profile-saliva\/","title":{"rendered":"Melatonine-profiel - speeksel"},"content":{"rendered":"<h4 data-start=\"816\" data-end=\"836\">Clinical focus<\/h4>\n<p><!--more--><\/p>\n<p data-start=\"837\" data-end=\"1024\">The Melatonin Profile provides an overview of a patient\u2019s <strong data-start=\"895\" data-end=\"916\">sleep\u2013wake rhythm<\/strong> by measuring salivary melatonin at several key time points over a single day. It is particularly useful in:<\/p>\n<ul>\n<li data-start=\"1028\" data-end=\"1073\">Difficulty falling asleep or staying asleep<\/li>\n<li data-start=\"1076\" data-end=\"1101\">Early-morning awakening<\/li>\n<li data-start=\"1104\" data-end=\"1191\">Suspected circadian rhythm disorders (e.g. delayed sleep phase, advanced sleep phase)<\/li>\n<li data-start=\"1194\" data-end=\"1241\">Jet lag and shift-work\u2013related sleep problems<\/li>\n<li data-start=\"1244\" data-end=\"1346\">Suspected low nocturnal melatonin output (e.g. with chronic stress, light exposure at night, ageing)<\/li>\n<li data-start=\"1349\" data-end=\"1494\">Mood disorders where disturbed circadian regulation is suspected (SAD, burnout, some depressive pictures)<\/li>\n<\/ul>\n<p data-start=\"1496\" data-end=\"1741\">Melatonin in saliva closely reflects unbound, biologically active melatonin in circulation and provides a practical alternative to blood measurements for assessing circadian timing and overnight secretion.<\/p>\n<h4 data-start=\"1748\" data-end=\"1760\">Analytes<\/h4>\n<p data-start=\"1762\" data-end=\"1831\">The profile includes <strong data-start=\"1783\" data-end=\"1830\">four timed melatonin measurements in saliva<\/strong>:<\/p>\n<ul>\n<li data-start=\"1835\" data-end=\"1900\"><strong data-start=\"1835\" data-end=\"1858\">Melatonin \u2013 Morning<\/strong> (approximately 30 minutes after waking)<\/li>\n<li data-start=\"1903\" data-end=\"1942\"><strong data-start=\"1903\" data-end=\"1925\">Melatonin \u2013 Midday<\/strong> (before lunch)<\/li>\n<li data-start=\"1945\" data-end=\"1986\"><strong data-start=\"1945\" data-end=\"1968\">Melatonin \u2013 Evening<\/strong> (before dinner)<\/li>\n<li data-start=\"1989\" data-end=\"2040\"><strong data-start=\"1989\" data-end=\"2010\">Melatonin \u2013 Night<\/strong> (shortly before going to bed)<\/li>\n<\/ul>\n<p data-start=\"2042\" data-end=\"2076\">This pattern allows assessment of:<\/p>\n<ul>\n<li data-start=\"2080\" data-end=\"2114\">Daytime suppression of melatonin<\/li>\n<li data-start=\"2117\" data-end=\"2154\">Onset and rise of evening melatonin<\/li>\n<li data-start=\"2157\" data-end=\"2195\">Adequacy of nocturnal peak secretion<\/li>\n<\/ul>\n<h4 data-start=\"2288\" data-end=\"2313\">Sample and collection<\/h4>\n<p data-start=\"2315\" data-end=\"2413\"><strong data-start=\"2315\" data-end=\"2331\">Sample type:<\/strong> Saliva, 4 tubes (patient home collection) <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]!\" href=\"https:\/\/www.rupahealth.com\/lab-tests\/doctors-data-melatonin-profile?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between\"><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">Rupa Health<\/span><span class=\"-me-1 flex h-full items-center rounded-full px-1 text-[#8F8F8F]\">+1<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<p data-start=\"2415\" data-end=\"2441\"><strong data-start=\"2415\" data-end=\"2434\">Collection day:<\/strong> 1 day.<\/p>\n<p data-start=\"2443\" data-end=\"2526\"><strong data-start=\"2443\" data-end=\"2486\">Standard collection schedule (example):<\/strong> <span class=\"\" data-state=\"closed\"><span class=\"ms-1 inline-flex max-w-full items-center relative top-[-0.094rem] animate-[show_150ms_ease-in]\" data-testid=\"webpage-citation-pill\"><a class=\"flex h-4.5 overflow-hidden rounded-xl px-2 text-[9px] font-medium transition-colors duration-150 ease-in-out text-token-text-secondary! bg-[#F4F4F4]! dark:bg-[#303030]!\" href=\"https:\/\/support.rupahealth.com\/en\/articles\/8552118-melatonin-profile?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noopener\"><span class=\"relative start-0 bottom-0 flex h-full w-full items-center\"><span class=\"flex h-4 w-full items-center justify-between overflow-hidden\"><span class=\"max-w-[15ch] grow truncate overflow-hidden text-center\">Rupa Health<\/span><\/span><\/span><\/a><\/span><\/span><\/p>\n<ol>\n<li data-start=\"2530\" data-end=\"2594\"><strong data-start=\"2530\" data-end=\"2548\">Morning sample<\/strong> \u2013 30 minutes after waking, before breakfast<\/li>\n<li data-start=\"2598\" data-end=\"2632\"><strong data-start=\"2598\" data-end=\"2615\">Midday sample<\/strong> \u2013 before lunch<\/li>\n<li data-start=\"2636\" data-end=\"2672\"><strong data-start=\"2636\" data-end=\"2654\">Evening sample<\/strong> \u2013 before dinner<\/li>\n<li data-start=\"2676\" data-end=\"2721\"><strong data-start=\"2676\" data-end=\"2692\">Night sample<\/strong> \u2013 just before going to bed<\/li>\n<\/ol>\n<p data-start=\"2723\" data-end=\"2744\">General instructions:<\/p>\n<ul>\n<li data-start=\"2748\" data-end=\"2819\">No food or drink (except water) for <strong data-start=\"2784\" data-end=\"2794\">1 hour<\/strong> before each collection<\/li>\n<li data-start=\"2822\" data-end=\"2888\">No brushing or flossing teeth for <strong data-start=\"2856\" data-end=\"2870\">30 minutes<\/strong> before sampling<\/li>\n<li data-start=\"2891\" data-end=\"2971\">Rinse the mouth with water, wait 10 minutes, then collect saliva into the tube<\/li>\n<li data-start=\"2974\" data-end=\"3052\">Fill each tube to the indicated mark, close firmly, label with date and time<\/li>\n<\/ul>\n<p data-start=\"3054\" data-end=\"3108\">Specific restrictions (you can adapt to your WHL SOP):<\/p>\n<ul>\n<li data-start=\"3112\" data-end=\"3191\">Avoid melatonin supplements for at least <strong data-start=\"3153\" data-end=\"3165\">36 hours<\/strong> before the first sample<\/li>\n<li data-start=\"3194\" data-end=\"3390\">On the collection day avoid caffeine, energy drinks and non-essential supplements\/medications that may interfere with melatonin (unless medically necessary)<\/li>\n<\/ul>\n<h4 data-start=\"3397\" data-end=\"3422\">Handling and shipping<\/h4>\n<ul>\n<li>After each collection, place the tube <strong data-start=\"3464\" data-end=\"3494\">immediately in the freezer<\/strong><\/li>\n<li>Keep all tubes <strong data-start=\"3514\" data-end=\"3524\">frozen<\/strong> together with the cold pack until shipment<\/li>\n<li>Ship the samples with the provided insulated packaging and cold pack, using the return label included in the kit<\/li>\n<li>Prefer <strong data-start=\"3696\" data-end=\"3719\">early-week shipping<\/strong> so samples do not sit over the weekend in transit<\/li>\n<\/ul>\n<h4 data-start=\"4089\" data-end=\"4154\">Interpretation \u2013 typical patterns<\/h4>\n<p data-start=\"4156\" data-end=\"4191\">The report will usually comment on:<\/p>\n<ul>\n<li><strong data-start=\"4195\" data-end=\"4214\">Normal profile:<\/strong> low daytime values with a clear rise in the evening and highest values at night<\/li>\n<li><strong data-start=\"4299\" data-end=\"4327\">Low nocturnal melatonin:<\/strong> may be associated with insomnia, ageing, excessive evening light exposure, beta-blocker use, or chronic stress<\/li>\n<li><strong data-start=\"4443\" data-end=\"4474\">Elevated daytime melatonin:<\/strong> can indicate circadian phase shift, inappropriate supplement timing, or sampling artefact<\/li>\n<li><strong data-start=\"4569\" data-end=\"4596\">Phase delay or advance:<\/strong> shift of the evening\/night peak later or earlier than expected, relevant in delayed sleep phase syndrome, shift-work and jet lag<\/li>\n<li>These patterns are interpreted in the context of symptoms, medication\/supplement use, and, if available, parallel cortisol or sleep questionnaires.<\/li>\n<\/ul>\n<h4 data-start=\"4923\" data-end=\"4984\">Scientific background<\/h4>\n<p data-start=\"4986\" data-end=\"5308\">Melatonin is a pineal hormone with a strong circadian pattern, peaking at night and suppressed by light. Salivary melatonin correlates well with plasma melatonin and is widely used for assessing dim-light melatonin onset (DLMO) and circadian phase in clinical and research set<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Geeft een momentopname van de slaap\/waakcyclus gedurende een periode van \u00e9\u00e9n dag.<\/p>","protected":false},"featured_media":10932,"template":"","meta":[],"product_brand":[],"product_cat":[352,140,304],"product_tag":[143,193,188,144,189],"class_list":{"0":"post-13312","1":"product","2":"type-product","3":"status-publish","4":"has-post-thumbnail","6":"product_cat-load-tests","7":"product_cat-panels","8":"product_cat-saliva-hormone","9":"product_tag-brain-function","10":"product_tag-energy","11":"product_tag-hormones","12":"product_tag-mood-balance","13":"product_tag-stress","14":"pa_sample-type-saliva","16":"first","17":"instock","18":"shipping-taxable","19":"purchasable","20":"product-type-simple"},"_links":{"self":[{"href":"https:\/\/www.worldhealthlaboratories.com\/nl\/wp-json\/wp\/v2\/product\/13312","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.worldhealthlaboratories.com\/nl\/wp-json\/wp\/v2\/product"}],"about":[{"href":"https:\/\/www.worldhealthlaboratories.com\/nl\/wp-json\/wp\/v2\/types\/product"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.worldhealthlaboratories.com\/nl\/wp-json\/wp\/v2\/media\/10932"}],"wp:attachment":[{"href":"https:\/\/www.worldhealthlaboratories.com\/nl\/wp-json\/wp\/v2\/media?parent=13312"}],"wp:term":[{"taxonomy":"product_brand","embeddable":true,"href":"https:\/\/www.worldhealthlaboratories.com\/nl\/wp-json\/wp\/v2\/product_brand?post=13312"},{"taxonomy":"product_cat","embeddable":true,"href":"https:\/\/www.worldhealthlaboratories.com\/nl\/wp-json\/wp\/v2\/product_cat?post=13312"},{"taxonomy":"product_tag","embeddable":true,"href":"https:\/\/www.worldhealthlaboratories.com\/nl\/wp-json\/wp\/v2\/product_tag?post=13312"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}